Sign In | Join Free | My spintoband.com
spintoband.com
Changsha Zhenxiang Biotechnology Co., Ltd.
Changsha Zhenxiang Biotechnology Co., Ltd. Factory Directly Supply Raw Steroid Powder, Steroid Injection, Peptides and Sarms
Home > Pharmaceutical Raw Materials >

Antineoplastic Letrozole Femara CGS-20267 Powder CAS 112809-51-5

Changsha Zhenxiang Biotechnology Co., Ltd.
Trust Seal
Verified Supplier
Credit Check
Supplier Assessment
Changsha Zhenxiang Biotechnology Co., Ltd.
City: Changsha
Province/State: Hunan
Country/Region: China
Tel: 00-86-13397492710
Contact Person:
Mr ableson

Antineoplastic Letrozole Femara CGS-20267 Powder CAS 112809-51-5

CAS NO. : 112809-51-5
Molecular Formula : C17H11N5
Molecular Weight : 285.3
Melting point : 181-183°C
Appearance : white to light yellow crystalline powder
Standard adopted : USP32
Brand Name : YC
Certification : HSE, ISO 9001, USP, BP
Place of Origin : China
Contact Now

Antineoplastic Letrozole Femara CGS-20267 Powder CAS 112809-51-5 oral non-steroidal aromatase inhibitor


Basic Info


Product NameLetrozole
CAS NO.112809-51-5

MF

C17H11N5

MW

285.3
Synonyms4,4'-(1H-1,2,4-TRIAZOL-1-YLMETHYLENE) BIS-BENZONITRILE; CGS-20267, Femara
Melting point181-183°C
storage temprature-20°C Freezer

What is Letrozole?


Letrozole (INN, trade name Femara) is an oral non-steroidal aromatase inhibitor for the treatment of hormonally-responsive breast cancer after surgery.It is a new generation of selective aromatase inhibitors.


How does Letrozole Work?


Letrozole is a new generation of selective aromatase inhibitors. It is a synthetic benzyl triazole derivative, can inhibit aromatase and decrease estrogen levels, further eliminates the stimulation of estrogen on tumor growth. The activity of letrozole in the body is 150-250 times more than that of the first generation of aromatase inhibitors-aminoglutethimide. Due to its high selectivity, and shall not affect the ugar cortical hormone, mineralocorticoid and thyroid functions, large dosage is of no inhibition for adrenal orticosteroid secretions, therefore, it has a higher therapeutic index. Preclinical studies have shown that Letrozole is of no potential toxicity to each system and target organ in the body, no mutagenic and carcinogenic effect, little side reaction, well tolerated, and compared with other aromatase inhibitors and anti-estrogen drugs, it has a stronger antitumor effect. Applicable to the treatment of advanced breast cancer in postmenopausal patients who anti-estrogen ineffective, and early breast cancer.


Estrogens are produced by the conversion of androgens through the activity of the aromatase enzyme. Estrogens then bind to an estrogen receptor, which causes cells to divide.

Letrozole is an aromatase inhibitor.

Letrozole prevents the aromatase from producing estrogens by competitive, reversible binding to the heme of its cytochrome P450 unit. The action is specific, and letrozole does not reduce production of mineralo- or corticosteroids.


Usage of Letrozole


(1)A nonsteroidal aromatase inhibitor structurally related to Fadrozole. Antineoplastic
(2)Pyrrole type aromatization enzyme inhibitors. Used in the treatment of breast cancer.


Adverse Reactions and Side Effects


Randomized trials show that orally take 2.5 mg of letrozole every day, adverse reactions incidence may be related to the drug is 33%, and is significantly less than that of the AG group which is 46%. Most adverse reactions of letrozole are mild or moderate, mainly include nausea (2%~9%), headache (0%~7%), bone pain (4%~10%), hot flashes (0%~9%) and weight gain (2%~8%), and other rare reactions like onstipation, diarrhea, itching, rash, joint pain, chest pain, abdominal pain, fatigue, insomnia, dizziness, edema, hypertension, arrhythmia, thrombosis, difficulty breathing, vaginal bleeding, etc.



Product Tags:

active pharmaceutical intermediates

      

pharmacy Steroids

      
China Customized Inflatable Bumper Ball Game Bubble Adult Grass CE supplier

Antineoplastic Letrozole Femara CGS-20267 Powder CAS 112809-51-5 Images

Inquiry Cart 0
Send your message to this supplier
 
From:
Enter your email please.
To: Changsha Zhenxiang Biotechnology Co., Ltd.
Subject:
Message:
Characters Remaining: (0/3000)
 
Inquiry Cart 0