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Antineoplastic Letrozole Femara CGS-20267 Powder CAS 112809-51-5

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Antineoplastic Letrozole Femara CGS-20267 Powder CAS 112809-51-5

CAS NO. : 112809-51-5
Molecular Formula : C17H11N5
Molecular Weight : 285.3
Melting point : 181-183°C
Appearance : white to light yellow crystalline powder
Standard adopted : USP32
Brand Name : Zhenxiang
Certification : HSE, ISO 9001, USP, BP
Place of Origin : CHINA
MOQ : Negotiable
Price : Negotiable
Supply Ability : 500kg/month
Delivery Time : Within 8 hours after payment is confirmed
Packaging Details : Specials
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Antineoplastic Letrozole Femara CGS-20267 Powder CAS 112809-51-5 oral non-steroidal aromatase inhibitor

Basic Info

Product NameLetrozole
CAS NO.112809-51-5




Synonyms4,4'-(1H-1,2,4-TRIAZOL-1-YLMETHYLENE) BIS-BENZONITRILE; CGS-20267, Femara
Melting point181-183°C
storage temprature-20°C Freezer

What is Letrozole?

Letrozole (INN, trade name Femara) is an oral non-steroidal aromatase inhibitor for the treatment of hormonally-responsive breast cancer after surgery.It is a new generation of selective aromatase inhibitors.

How does Letrozole Work?

Letrozole is a new generation of selective aromatase inhibitors. It is a synthetic benzyl triazole derivative, can inhibit aromatase and decrease estrogen levels, further eliminates the stimulation of estrogen on tumor growth. The activity of letrozole in the body is 150-250 times more than that of the first generation of aromatase inhibitors-aminoglutethimide. Due to its high selectivity, and shall not affect the ugar cortical hormone, mineralocorticoid and thyroid functions, large dosage is of no inhibition for adrenal orticosteroid secretions, therefore, it has a higher therapeutic index. Preclinical studies have shown that Letrozole is of no potential toxicity to each system and target organ in the body, no mutagenic and carcinogenic effect, little side reaction, well tolerated, and compared with other aromatase inhibitors and anti-estrogen drugs, it has a stronger antitumor effect. Applicable to the treatment of advanced breast cancer in postmenopausal patients who anti-estrogen ineffective, and early breast cancer.

Estrogens are produced by the conversion of androgens through the activity of the aromatase enzyme. Estrogens then bind to an estrogen receptor, which causes cells to divide.

Letrozole is an aromatase inhibitor.

Letrozole prevents the aromatase from producing estrogens by competitive, reversible binding to the heme of its cytochrome P450 unit. The action is specific, and letrozole does not reduce production of mineralo- or corticosteroids.

Usage of Letrozole

(1)A nonsteroidal aromatase inhibitor structurally related to Fadrozole. Antineoplastic
(2)Pyrrole type aromatization enzyme inhibitors. Used in the treatment of breast cancer.

Adverse Reactions and Side Effects

Randomized trials show that orally take 2.5 mg of letrozole every day, adverse reactions incidence may be related to the drug is 33%, and is significantly less than that of the AG group which is 46%. Most adverse reactions of letrozole are mild or moderate, mainly include nausea (2%~9%), headache (0%~7%), bone pain (4%~10%), hot flashes (0%~9%) and weight gain (2%~8%), and other rare reactions like onstipation, diarrhea, itching, rash, joint pain, chest pain, abdominal pain, fatigue, insomnia, dizziness, edema, hypertension, arrhythmia, thrombosis, difficulty breathing, vaginal bleeding, etc.

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